Pathobiology of neutrophil transepithelial migration: implications in mediating epithelial injury.

@article{Chin2007PathobiologyON,
  title={Pathobiology of neutrophil transepithelial migration: implications in mediating epithelial injury.},
  author={Alex C. Chin and Charles A Parkos},
  journal={Annual review of pathology},
  year={2007},
  volume={2},
  pages={111-43}
}
Neutrophil (also known as polymorphonuclear leukocyte, or PMN) transepithelial migration and accumulation at mucosal surfaces is a hallmark of many inflammatory conditions. This process correlates directly with clinical disease activity and epithelial injury. Currently, the mechanisms that define PMN epithelial interactions during an inflammatory response are not completely understood. This review provides an overview of the consequences of PMN infiltration into epithelial tissues and… CONTINUE READING