Pathobiology of HIV/SIV-associated changes in secondary lymphoid tissues.

@article{Estes2013PathobiologyOH,
  title={Pathobiology of HIV/SIV-associated changes in secondary lymphoid tissues.},
  author={Jacob D Estes},
  journal={Immunological reviews},
  year={2013},
  volume={254 1},
  pages={
          65-77
        }
}
Acquired immunodeficiency syndrome (AIDS) is principally a disease of lymphoid tissues (LTs), due to the fact that the main target cell of human immunodeficiency virus (HIV) is the CD4(+) T lymphocyte that primarily resides within organs of the immune system. The impact of HIV infection on secondary LTs, in particular lymph nodes, is critical to delineate, as these immune organs are the principal sites for initiating and facilitating immune responses and are critical for lymphocyte homeostatic… CONTINUE READING
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