Pathobiological Effects of Acrolein in Cultured Human Bronchial Epithelial Cells

  title={Pathobiological Effects of Acrolein in Cultured Human Bronchial Epithelial Cells},
  author={Roland C Grafstr{\"o}m and Jeannette M. Dypbukt and James C. Willey and K Sundqvist and C C Edman and L. Atzori and Curtis C. Harris},
  journal={Cancer research},
  volume={48 7},
The ability of the highly reactive aldehyde acrolein to affect growth, membrane integrity, differentiation, and thiol status and to cause DNA damage has been studied at serum- and thiol-free conditions using cultured human bronchial epithelial cells. Acrolein markedly decreases colony survival at 3 microM whereas about 10-fold higher concentrations are required to increase membrane permeability, measured as uptake of trypan blue dye. Acrolein at micromolar concentrations also causes epithelial… CONTINUE READING


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