Pathobiochemistry of the extrapyramidal system: a “short note” review

  title={Pathobiochemistry of the extrapyramidal system: a “short note” review},
  author={P. Riederer and E. Sofi{\'c} and W. Rausch and G. Hebenstreit and J. Bruinvels},
  • P. Riederer, E. Sofić, +2 authors J. Bruinvels
  • Published 1989
  • Medicine
  • Evidence is presented to show that in Parkinson’s disease (PD) there exists a topographical degeneration in the nigrostriatal dopamine system. This finding may account for response variabilities and side effects occuring after antiparkinsonian therapy. Postsynaptic receptors do not show topical differences in both Bmax- and KD-values in treated PD. Postsynaptic receptors respond inadequately in about 30% of PD. Denervation supersensitivity may only occur in striatal subareas depleted of… CONTINUE READING
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