Pathobiochemical signatures of cholestatic liver disease in bile duct ligated mice

  title={Pathobiochemical signatures of cholestatic liver disease in bile duct ligated mice},
  author={Kerstin Abshagen and Matthias K{\"o}nig and Andreas Hoppe and Isabell M{\"u}ller and Matthias Ebert and Honglei Weng and Hermann-Georg Holzh{\"u}tter and Ulrich M. Zanger and Johannes G. Bode and Brigitte Vollmar and Maria Thomas and Steven Dooley},
  booktitle={BMC Systems Biology},
Disrupted bile secretion leads to liver damage characterized by inflammation, fibrosis, eventually cirrhosis, and hepatocellular cancer. As obstructive cholestasis often progresses insidiously, markers for the diagnosis and staging of the disease are urgently needed. To this end, we compiled a comprehensive data set of serum markers, histological parameters and transcript profiles at 8 time points of disease progression after bile duct ligation (BDL) in mice, aiming at identifying a set of… CONTINUE READING


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