Pathfinding of Corticothalamic Axons Relies on a Rendezvous with Thalamic Projections

  title={Pathfinding of Corticothalamic Axons Relies on a Rendezvous with Thalamic Projections},
  author={M. Deck and Ludmilla Lokmane and Sophie Chauvet and Caroline Mailhes and Maryama Keita and Mathieu Niquille and Michio Yoshida and Yutaka Yoshida and Cecile Lebrand and Fanny Mann and Elizabeth Ann Grove and Sonia Garel},
Major outputs of the neocortex are conveyed by corticothalamic axons (CTAs), which form reciprocal connections with thalamocortical axons, and corticosubcerebral axons (CSAs) headed to more caudal parts of the nervous system. Previous findings establish that transcriptional programs define cortical neuron identity and suggest that CTAs and thalamic axons may guide each other, but the mechanisms governing CTA versus CSA pathfinding remain elusive. Here, we show that thalamocortical axons are… CONTINUE READING
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