Pathfinding errors of corticospinal axons in neural cell adhesion molecule-deficient mice.

@article{Rolf2002PathfindingEO,
  title={Pathfinding errors of corticospinal axons in neural cell adhesion molecule-deficient mice.},
  author={Bettina Rolf and Martin Bastmeyer and Melitta Schachner and Udo Bartsch},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 19},
  pages={8357-62}
}
The neural cell adhesion molecule (NCAM) is a cell recognition molecule of the Ig superfamily implicated in cell migration, myelination, and synaptic plasticity, as well as elongation, fasciculation, and pathfinding of axons. Here, we used NCAM-deficient mice to investigate the role of NCAM in the development of the corticospinal tract. We demonstrate severe hypoplasia of the corticospinal tract in adult NCAM mutants. Anterograde tracing of the tract of early postnatal NCAM mutants revealed… CONTINUE READING

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