Path Forward for RAF Therapies: Inhibition of Monomers and Dimers.

@article{Kortum2015PathFF,
  title={Path Forward for RAF Therapies: Inhibition of Monomers and Dimers.},
  author={Robert L Kortum and Deborah K. Morrison},
  journal={Cancer cell},
  year={2015},
  volume={28 3},
  pages={279-81}
}
Current BRAF inhibitors block signaling from monomeric BRAF(V600E), but not from oncogenic RAS, which requires RAF dimerization. In this issue of Cancer Cell, Yao and colleagues investigate why current drugs are ineffective against RAF dimers, while Peng and colleagues describe a pan-RAF inhibitor targeting both monomeric and dimeric RAF. 

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