Paternal versus Maternal Inactivation in the X Chromosome of Female Mice

@article{Chandley1969PaternalVM,
  title={Paternal versus Maternal Inactivation in the X Chromosome of Female Mice},
  author={Ann C. Chandley},
  journal={Nature},
  year={1969},
  volume={221},
  pages={70-70}
}
EVANS et al.1 have shown that a “late labelling” X chromosome occurs in normal somatic cells of the mouse. Using female mice, heterozygous for the Cattanach translocation, in which an autosomal segment is inserted into an X chromosome making the translocated chromosome (Xt) recognizable as the longest member of the complement2, they showed that this abnormally long chromosome was “hot” in about half the cells that contained a late-labelling chromosome. In the remaining cells, the hot chromosome… CONTINUE READING