Paternal transmission of mitochondrial DNA is (fortunately) rare

@article{Johns2003PaternalTO,
  title={Paternal transmission of mitochondrial DNA is (fortunately) rare},
  author={Donald R. Johns},
  journal={Annals of Neurology},
  year={2003},
  volume={54}
}
  • D. Johns
  • Published 1 October 2003
  • Medicine
  • Annals of Neurology
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Genotypes from patients indicate no paternal mitochondrial DNA contribution
TLDR
It is suggested that paternal transmission of mtDNA is rare and should not alter genetic advice to families, and that strict maternal inheritance should not be changed.
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The cumulative results support the original conclusion that the pedigree divergence rate for the control region is approximately 10-fold higher than that obtained with phylogenetic analyses.
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The future challenge for biologists is to comprehend the nature of the selective destruction of paternal mitochondria, as it appears to be a species-specific recognition phenomenon.
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Ten sporadic patients with skeletal muscle‐restricted mtDNA mutations: five harbored mtDNA point mutations in protein‐coding genes and five had single mtDNA deletions, and haplotype analysis and direct sequencing of the hypervariable regions 1 and 2 of the D‐loop were performed.
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