Paternal inheritance of mitochondrial DNA in mice

  title={Paternal inheritance of mitochondrial DNA in mice},
  author={U. Gyllensten and D. Wharton and Agneta Josefsson and A. C. Wilson},
  • U. Gyllensten, D. Wharton, +1 author A. C. Wilson
  • Published 1991
  • Biology, Medicine
  • Nature
  • FOR nearly 20 years it has been assumed on the basis of low-resolution experiments that mitochondrial (mt)DNA, in contrast to the genes in the nucleus, has an exclusively maternal mode of inheritance in animals1. Using the polymerase chain reaction2, 3, paternally inherited mtDNA molecules have now been detected in mice at a frequency of 10−4, relative to the maternal contributions. These mice were hybrids between two inbred strains (C57BL/6J and Mus spretus) whose mtDNAs can be distinguished… CONTINUE READING
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