Paternal inheritance of mitochondrial DNA in mice

  title={Paternal inheritance of mitochondrial DNA in mice},
  author={Ulf Gyllensten and Dan Wharton and Agneta Josefsson and Allan Charles Wilson},
FOR nearly 20 years it has been assumed on the basis of low-resolution experiments that mitochondrial (mt)DNA, in contrast to the genes in the nucleus, has an exclusively maternal mode of inheritance in animals1. Using the polymerase chain reaction2, 3, paternally inherited mtDNA molecules have now been detected in mice at a frequency of 10−4, relative to the maternal contributions. These mice were hybrids between two inbred strains (C57BL/6J and Mus spretus) whose mtDNAs can be distinguished… 

Paternal comeback in mitochondrial DNA inheritance

  • J. Vissing
  • Biology
    Proceedings of the National Academy of Sciences
  • 2019
This report in PNAS reports on biparental inheritance in three families, which challenges the notion of strict maternal transmission of mtDNA to offspring.

Analysis of paternal transmission of mitochondrial DNA in Drosophila.

The present results indicate that paternal leakage occurs in the intraspecific crosses as well as in the interspecific crosses in Drosophila.

No recombination of mtDNA after heteroplasmy for 50 generations in the mouse maternal germline

No germline recombination after transmission of mtDNA under genetically and evolutionary relevant conditions in mammals is found and a method based on cloning of single mtDNA molecules in the λ phage, without prior PCR amplification, followed by subsequent mutation analysis is validated.

Direct evidence for extensive paternal mitochondrial DNA inheritance in the marine mussel Mytilus

Results from pair-matings involving two species of mussels show extensive contribution of paternal mtDNA, amounting to several orders of magnitude higher than that inferred for Drosophila or mice, was observed in both intra-and interspecific crosses.

The mitochondrial genome in embryo technologies.

Future directions of research on mtDNA in the context of reproductive biotechnology range from the elimination of adverse effects of artificial heteroplasmy, e.g. created by ooplasm transfer, to engineering of optimized constellations of nuclear and cytoplasmic genes for the production of superior livestock.

Keeping mtDNA in Shape between Generations

Recent literature on the transmission of mtDNA in animals and the implications for human health and ageing are outlined and highlighted.

Further evidence for paternal inheritance of mitochondrial DNA in the sheep (Ovis aries)

The mitochondrial DNA of 172 sheep from 48 families were typed by using PCR-RFLP, direct amplification of the repeated sequence domain and sequencing analysis, providing direct evidence of paternal inheritance of mitochondria DNA in sheep.



Maternal inheritance of mitochondrial DNA during backcrossing of two species of mice.

As judged by restriction analysis, mitochondrial DNA shows strictly maternal inheritance during 6-8 generations of backcrossing in both directions between Mus domesticus and Mus spretus. The average

Incomplete maternal transmission of mitochondrial DNA in Drosophila.

The possibility of incomplete maternal transmission of mitochondrial DNA (mtDNA) in Drosophila, previously suggested by the presence of heteroplasmy, was examined by intra- and interspecific backcrosses of Dosophila simulans and its closest relative, Drosophile mauritiana, and showed clear evidence for paternal leakage of mtDNA.

Nucleotide sequence evidence for rapid genotypic shifts in the bovine mitochondrial DNA D-loop

The nucleotide sequence of all or part of the D-loop region in 14 maternally related Holstein cows is determined to help answer the question of how individual variant mtDNA molecules resulting from mutational events can come to dominate the large intracellular mtDNA population so rapidly.

Mitochondrial DNA evolution in mice.

Fossil and other evidence is discussed for the view that in mice, as in many other mammals, the average rate of point mutational divergence in mtDNA is 2-4% per million years.

Mitochondrial DNA polymorphism in a maternal lineage of Holstein cows.

  • W. HauswirthP. Laipis
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1982
The present pattern of genotypes within the lineage demands that multiple shifts between genotypes must have occurred within the past 20 years with the most rapid shift taking place in no more than 4 years and indicates that mitochondrial DNA polymorphism can occur between maternally related mammals.

Heteroplasmy suggests limited biparental inheritance of Mytilus mitochondrial DNA.

Mussels of the Mytilus edulis species group appear to be exceptions to strict maternal inheritance of mitochondrial DNA, which is commonly observed in animals, but these observations are best explained by the hypothesis that biparental Inherited Mitochondrial DNA can occur in MyTilus.

Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies

Observations demonstrate that mtDNA heteroplasmy can occur in man and that human disease may be associated with defects of the mitochondrial genome.

Most classical Mus musculus domesticus laboratory mouse strains carry a Mus musculus musculus Y chromosome

Using a Y-specific genomic DNA probe obtained from a flow-sorted mouse Y-chromosome library, this work has examined the RFLPs in 10 newly established mouse lines of the European semispecies, and identified two variant forms of the Y chromosome, each of which is characteristic of one of the sem ispecies.