Paternal hyperglycemia in rats exacerbates the development of obesity in offspring.

@article{Shi2017PaternalHI,
  title={Paternal hyperglycemia in rats exacerbates the development of obesity in offspring.},
  author={Xiaoqin Shi and Xinyu Li and Yi Hou and Xuemei Cao and Yuyao Zhang and Heng Wang and Hongyin Wang and Chuan Sheng Peng and Jibin Li and Qifu Li and Chaodong Wu and Xiaoqiu Xiao},
  journal={The Journal of endocrinology},
  year={2017},
  volume={234 2},
  pages={
          175-186
        }
}
Parental history with obesity or diabetes will increase the risk for developing metabolic diseases in offspring. However, literatures as to transgenerational inheritance of metabolic dysfunctions through male lineage are relatively scarce. In the current study, we aimed to evaluate influences of paternal hyperglycemia on metabolic phenotypes in offspring. Male SD rats were i.p. injected with streptozotocin (STZ) or citrate buffer (CB, as control). STZ-injected rats with glucose levels higher… CONTINUE READING
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