Paternal exposure to ethylnitrosourea results in transgenerational genomic instability in mice.

@article{Dubrova2008PaternalET,
  title={Paternal exposure to ethylnitrosourea results in transgenerational genomic instability in mice.},
  author={Yuri E. Dubrova and Peter T. Hickenbotham and Colin D Glen and Karen Monger and Hiu-Pak Wong and Ruth C. Barber},
  journal={Environmental and molecular mutagenesis},
  year={2008},
  volume={49 4},
  pages={308-11}
}
Recent data shows that the effects of ionizing radiation are not restricted to the directly exposed parental germ cells, but can also manifest in their nonexposed offspring, resulting in elevated mutation rates and cancer predisposition. The mechanisms underlying these transgenerational changes remain poorly understood. One of the most important steps in elucidating these mechanisms is to investigate the initial cellular events that trigger genomic instability. Here we have analyzed the effects… CONTINUE READING

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