Paternal concentrations of dioxin and sex ratio of offspring

@article{Mocarelli2000PaternalCO,
  title={Paternal concentrations of dioxin and sex ratio of offspring},
  author={Paolo Mocarelli and Pier Mario Gerthoux and E Ferrari and Donald G. Patterson and Stephanie M. Kieszak and Paolo Brambilla and Nicoletta Vincoli and Stefano G. Signorini and Pierluigi Tramacere and Vittorio Carreri and Eric J. Sampson and Wayman E. Turner and Larry L. Needham},
  journal={The Lancet},
  year={2000},
  volume={355},
  pages={1858-1863}
}
BACKGROUND 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD or dioxin), is commonly considered the most toxic man-made substance. We have previously shown that high serum concentrations of TCDD in parents from Seveso, Italy, were linked to their having a relative increase in the number of female births after the parents exposure to a release of dioxin in 1976. We have continued the study to determine whether the parents' sex and/or age at exposure affected the sex ratio of their children. METHODS We… 
Sex ratios of children of Russian pesticide producers exposed to dioxin.
TLDR
Human exposure of these pesticide producers to high levels of dioxins is associated with the birth of more girls, but only for paternal exposures.
Sex ratio of the offspring of New Zealand phenoxy herbicide producers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin
TLDR
It is indicated that paternal serum TCDD concentrations in excess of an estimated 20 pg/g lipid at time of conception are associated with a reduced sex ratio.
A cohort study of in utero polychlorinated biphenyl (PCB) exposures in relation to secondary sex ratio
TLDR
Maternal exposure to PCBs may be detrimental to the success of male sperm or to the survival of male embryos, and some congener-specific associations with sex ratio were only marginally statistically significant.
Does paternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) affect the sex ratio of offspring?
TLDR
It is confirmed that direct paternal exposure to TCDD might be associated with an alteration in the sex ratio of offspring, and possible mechanisms through which TCDd might decrease the fertility potential of Y-bearing gametes before conception are discussed.
Spontaneous abortion, sex ratio, and paternal occupational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
TLDR
The estimated T CDD levels in this exposed worker population were much higher than in other studies, providing additional evidence that paternal TCDD exposure does not increase the risk of spontaneous abortion at levels above those observed in the general population.
Offspring sex ratios of people exposed to dioxin and dioxin-like compounds
  • W. James
  • Medicine
    Occupational and environmental medicine
  • 2002
TLDR
It is inferred that sex ratio is unlikely to be a sensitive indicator of exposures to chemicals such as PCBs, PCDFs, and dioxins, and that in Taiwan, despite exposure to chemicals similar to TCDD sufficient to produce obvious clinical disease, the sex ratio was not altered.
DECREASED SEX RATIO FOLLOWING MATERNAL EXPOSURE TO POLYCHLORINATED BIPHENYLS FROM CONTAMINATED GREAT LAKES SPORT-CAUGHT FISH
TLDR
Findings suggest that maternal exposure to polychlorinated biphenyls may decrease the sex ratio of offspring, adding to the growing body of evidence that exposure to particular chemicals can alter the sex ratios at birth.
Environmental pollutants and male-to-female birth ratios.
TLDR
The adverse effects of environmental pollutants described in this article on the birth ratio are not conclusive and there was a decrease in the proportion of male newborns born to pregnant women who were exposed to polychlorinated biphenyls by the consumption of goods that were contaminated with PCBs in the Great Lakes.
Decreased sex ratio following maternal exposure to polychlorinated biphenyls from contaminated Great Lakes sport-caught fish: a retrospective cohort study.
TLDR
Findings suggest that maternal exposure to polychlorinated biphenyls may decrease the sex ratio of offspring, adding to the growing body of evidence that exposure to particular chemicals can alter the sex ratios at birth.
Relationship of serum TCDD concentrations and age at exposure of female residents of Seveso, Italy.
TLDR
Zone of residence and age were the strongest predictors of TCDD level, and previous SWHS studies that considered only T CDD exposure may have underestimated health effects due to total TEQ concentrations.
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TLDR
Between 1977 and 1984, 48 girls but only 26 boys were born to parents exposed to 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) in Seveso, Italy, which represents about one half-life of TCDD in adult human beings.
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TLDR
Men exposed to dioxin-contaminated wood preservatives sire an excess of daughters, a further example of how offspring sex ratios can serve as indicators of reproductive hazards to men.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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