Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β-cell mass by epigenetic modification of Cdkn1c.

@article{Asahara2015PaternalAM,
  title={Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β-cell mass by epigenetic modification of Cdkn1c.},
  author={Shun-Ichiro Asahara and Hiroaki Etoh and Hiroyuki Inoue and Kyoko Teruyama and Yuki Shibutani and Yuka Ihara and Yukina Kawada and Alberto Bartolom{\'e} and Naoko Hashimoto and Tomokazu Matsuda and Maki Koyanagi-Kimura and Ayumi Kanno and Yushi Hirota and Tetsuya Hosooka and Kazuaki Nagashima and Wataru Nishimura and Hiroshi Inoue and Michihiro Matsumoto and Michael J Higgins and Kazuki Yasuda and Nobuya Inagaki and Susumu Seino and Masato Kasuga and Yoshiaki Kido},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 27},
  pages={
          8332-7
        }
}
Genetic factors are important determinants of the onset and progression of diabetes mellitus. Numerous susceptibility genes for type 2 diabetes, including potassium voltage-gated channel, KQT-like subfamily Q, member1 (KCNQ1), have been identified in humans by genome-wide analyses and other studies. Experiments with genetically modified mice have also implicated various genes in the pathogenesis of diabetes. However, the possible effects of the parent of origin for diabetes susceptibility… CONTINUE READING
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