Paternal Stress Exposure Alters Sperm MicroRNA Content and Reprograms Offspring HPA Stress Axis Regulation

@article{Rodgers2013PaternalSE,
  title={Paternal Stress Exposure Alters Sperm MicroRNA Content and Reprograms Offspring HPA Stress Axis Regulation},
  author={A. Rodgers and C. P. Morgan and Stefanie L. Bronson and Sonia D. Revello and T. Bale},
  journal={The Journal of Neuroscience},
  year={2013},
  volume={33},
  pages={9003 - 9012}
}
Neuropsychiatric disease frequently presents with an underlying hyporeactivity or hyperreactivity of the HPA stress axis, suggesting an exceptional vulnerability of this circuitry to external perturbations. Parental lifetime exposures to environmental challenges are associated with increased offspring neuropsychiatric disease risk, and likely contribute to stress dysregulation. While maternal influences have been extensively examined, much less is known regarding the specific role of paternal… Expand
528 Citations
Transgenerational Epigenetic Mechanisms of Stress Axis Programming
  • Highly Influenced
Parental Advisory: Maternal and Paternal Stress Can Impact Offspring Neurodevelopment
  • 77
  • PDF
Intergenerational Mechanisms Of Paternal Stress Transmission
Germ Cell Origins of Posttraumatic Stress Disorder Risk: The Transgenerational Impact of Parental Stress Experience
  • 49
  • PDF
Lifetime stress experience: transgenerational epigenetics and germ cell programming
  • T. Bale
  • Biology, Medicine
  • Dialogues in clinical neuroscience
  • 2014
  • 80
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 81 REFERENCES
Sex-Specific Programming of Offspring Emotionality after Stress Early in Pregnancy
  • 836
  • PDF
Paternal Transmission of Stress-Induced Pathologies
  • 256
  • Highly Influential
  • PDF
Glucocorticoids, prenatal stress and the programming of disease
  • 699
Early Prenatal Stress Epigenetically Programs Dysmasculinization in Second-Generation Offspring via the Paternal Lineage
  • 269
  • PDF
Impact of prenatal stress on long term body weight is dependent on timing and maternal sensitivity
  • 155
Epigenetics and the origins of paternal effects
  • 324
  • PDF
...
1
2
3
4
5
...