Paternal Stress Exposure Alters Sperm MicroRNA Content and Reprograms Offspring HPA Stress Axis Regulation

@article{Rodgers2013PaternalSE,
  title={Paternal Stress Exposure Alters Sperm MicroRNA Content and Reprograms Offspring HPA Stress Axis Regulation},
  author={Ali B. Rodgers and Christopher P. Morgan and Stefanie L. Bronson and Sonia D. Revello and Tracy L. Bale},
  journal={The Journal of Neuroscience},
  year={2013},
  volume={33},
  pages={9003 - 9012}
}
Neuropsychiatric disease frequently presents with an underlying hyporeactivity or hyperreactivity of the HPA stress axis, suggesting an exceptional vulnerability of this circuitry to external perturbations. Parental lifetime exposures to environmental challenges are associated with increased offspring neuropsychiatric disease risk, and likely contribute to stress dysregulation. While maternal influences have been extensively examined, much less is known regarding the specific role of paternal… 

Figures and Tables from this paper

Transgenerational Epigenetic Mechanisms of Stress Axis Programming

Research presented in this dissertation support that epigenetic mechanisms mediate the transgenerational transmission of chronic stress and allow lifetime adversity to program later stress dysregulation.

Intergenerational Mechanisms Of Paternal Stress Transmission

Evidence is provided for the specificity of paternal stress sperm microRNA effects on embryonic brain and placental transcriptomes, indicating a tightly regulated process by which sperm micro RNA are coordinated and function to influence offspring development.

Elevated paternal glucocorticoid exposure alters the small noncoding RNA profile in sperm and modifies anxiety and depressive phenotypes in the offspring

Evidence is provided that sustained elevation of glucocorticoids is involved in the transmission of paternal stress-induced traits across generations in a process involving small noncoding RNA signals transmitted by the male germline.

eview tress-induced perinatal and transgenerational epigenetic rogramming of brain development and mental health

The evidence of transgenerational epigenetic inheritance of stress exposure in human studies and animal models is discussed and it is proposed that prenatal stress, through the generation of epigenetic alterations, becomes one of the most powerful influences on mental health in later life.

Profiling nonhuman primate germline RNA to understand the legacy of early life stress

This study used a translational nonhuman primate model of ELS caused by naturally occurring adverse caregiving of infant macaques to profile total RNA in the adolescent male germline, and identify how those RNA profiles are affected by exposure to ELS.

Lifetime stress experience: transgenerational epigenetics and germ cell programming

  • T. Bale
  • Psychology, Biology
    Dialogues in clinical neuroscience
  • 2014
Animal models of parental stress have examined relevant offspring phenotypes and transgenerational outcomes, and provided unique insight into the germ cell epigenetic changes associated with disruptions in neurodevelopment.
...

References

SHOWING 1-10 OF 70 REFERENCES

Sex-Specific Programming of Offspring Emotionality after Stress Early in Pregnancy

The results indicate that stress experience early in pregnancy may contribute to male neurodevelopmental disorders through impacts on placental function and fetal development.

Paternal Transmission of Stress-Induced Pathologies

Glucocorticoids, prenatal stress and the programming of disease

Early Prenatal Stress Epigenetically Programs Dysmasculinization in Second-Generation Offspring via the Paternal Lineage

Overall, these data support the existence of a sensitive period of early gestation when epigenetic programming of the male germline can occur, permitting transmission of specific phenotypes into subsequent generations.

Prenatal stress modifies behavior and hypothalamic-pituitary-adrenal function in female guinea pig offspring: effects of timing of prenatal stress and stage of reproductive cycle.

It is demonstrated that there are effects of prenatal stress on behavior and HPA axis functioning in female offspring but that the outcomes are dependent on the timing of the prenatal stress together with the status of the reproductive cycle.

Impact of prenatal stress on long term body weight is dependent on timing and maternal sensitivity

Epigenetics and the origins of paternal effects

Sex differences in the serotonergic influence on the hypothalamic-pituitary-adrenal stress axis.

Data suggest that multiple sites related to 5-HTergic stimulation, corticosterone production, and negative feedback of HPA neurocircuitry combine to produce higher female stress responsiveness, supporting a potential for sex-specific involvement of 5- HT and stress pathways in the etiology of affective disorders.
...