Paternal Programming of Liver Function and Lipid Profile Induced by a Paternal Pre-Conceptional Unhealthy Diet: Potential Association with Altered Gut Microbiome Composition.

@article{Zhang2019PaternalPO,
  title={Paternal Programming of Liver Function and Lipid Profile Induced by a Paternal Pre-Conceptional Unhealthy Diet: Potential Association with Altered Gut Microbiome Composition.},
  author={Xiaoli Zhang and Yunpeng Dong and Guoying Sun and Ahmed Abdallah Hasan and Mei Zi Tian and Suimin Zeng and Jing Li and Shiyu Zeng and Jun Ma and Jian Li and Berthold Hocher},
  journal={Kidney & blood pressure research},
  year={2019},
  volume={44 1},
  pages={
          133-148
        }
}
BACKGROUND/AIMS Paternal exposure to adverse environmental conditions can act on offspring's phenotype and influence offspring's later life disease risk. Our study was designed to examine the effect of feeding male rats before mating a high-fat, high-sucrose and high-salt diet (HFSSD) over two generations (F0 and F1) on their offspring's (F2) liver function and gut microbiome composition. METHODS Male F0 rats and male F1 rats were fed either control diet or HFSSD before mating. Liver function… CONTINUE READING