Paternal Cyclophosphamide Exposure Induces the Formation of Functional Micronuclei during the First Zygotic Division


Paternal exposures to cancer chemotherapeutics or environmental chemicals may have adverse effects on progeny outcome that are manifested in the preimplantation embryo. The objectives of this study were to determine the impact of paternal exposure to cyclophosphamide, an anticancer alkylating agent, on the formation, chromatin origin and function of… (More)
DOI: 10.1371/journal.pone.0027600


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