Paternal Age and Spontaneous Abortion

@article{Kleinhaus2006PaternalAA,
  title={Paternal Age and Spontaneous Abortion},
  author={Karine Kleinhaus and Mary C. Perrin and Yechiel Friedlander and Ora Paltiel and Dolores Malaspina and Susan Harlap},
  journal={Obstetrics \& Gynecology},
  year={2006},
  volume={108},
  pages={369-377}
}
OBJECTIVE: To evaluate the influence of paternal age upon spontaneous abortion. METHODS: This case–control study of 13,865 women draws on data from women's antenatal or postpartum interviews in the Jerusalem Perinatal Study, a population-based cohort derived from 92,408 births in 1964–1976. Case women (n=1,506) reported spontaneous abortion in the pregnancy preceding the interview; they were compared with women reporting live births in their previous pregnancy (n=12,359). Logistic regression… 

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It was found that women with high blood pressure have 63% less odds for nonspontaneous abortion, which is statistically significant (p value < 0.05).

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Paternal age beyond 35 years was found to be significantly related to first trimester spontaneous miscarriages.

Paternal age and twinning in the Jerusalem Perinatal Study.

PATTERN AND DETERMINANTS FOR TERMINATION OF PREGNANCY IN LAHORE , PAKISTAN

Major fetal indications included multiple malformations and abnormal implantation while maternal indications included hypertension/Pre eclampsia/E clampsia and diabetes.

The Effect of Paternal Age on Fetal Birth Outcomes

It is demonstrated that paternal age influences birth outcomes and warrants further investigation, whereas those born to fathers aged 24 years or younger had an elevated likelihood of experiencing these same adverse outcomes.

Influence of paternal age on perinatal outcomes

Paternal age and mortality in children

A U-shaped association between paternal age and the overall mortality rate in children up to 18 years of age is observed and adds to the cumulating evidence on adverse effects of advanced paternal age in procreation.

Elevated risks of pregnancy complications and adverse outcomes with increasing maternal age.

The risks for most outcomes paralleled increasing maternal age including prolonged and dysfunctional labour, excessive labour bleeding, breech and malpresentation and primary Caesarean delivery.
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References

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The risk of spontaneous abortion increased with increasing paternal age, with a suggestion that the association is stronger for first trimester losses.

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The paternal age-related risk of late fetal death was higher than the risk of early fetal death and started to increase from the age of 45 years, which should be interpreted cautiously because of the restricted number of fetal deaths.

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Spontaneous abortion was also associated with daily consumption of more than 150 mg of caffeine, abdominal trauma, infection and fever during pregnancy, and no significant association emerged with mater nal age, social class, education, exposure to video display terminals, parity, use of contraception, diabetes or obesity.

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Both maternal age and paternal age effects on miscarriage risk are investigated to provide insight into this frequent reproductive failure and it is found that the risk of miscarriage was higher if the woman was aged > or = 35 years, as has already been reported in a number of studies.

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