Patent foramen ovale implicated in high-altitude pulmonary edema

  title={Patent foramen ovale implicated in high-altitude pulmonary edema},
  journal={Nature Clinical Practice Cardiovascular Medicine},
  • Published 2007
  • Nature Clinical Practice Cardiovascular Medicine
Arterial hypoxemia and exaggerated pulmonary hypertension are features of high-altitude pulmonary edema (HAPE), but the underlying mechanisms of their relationship with this condition are unclear. Allemann et al. recruited 35 mountaineers and classified them according to whether they had any history of clinically and radio graphically documented HAPE—16 were categorized as being susceptible to HAPE (HAPE-S) and 19 as HAPE-resistant (HAPE-R). Participants embarked on an ascent and were tested at… Expand