Patent Foramen Ovale Closure or Antiplatelet Therapy for Cryptogenic Stroke.

  title={Patent Foramen Ovale Closure or Antiplatelet Therapy for Cryptogenic Stroke.},
  author={L. G. S\ondergaard and Scott E Kasner and John F. Rhodes and Grethe Andersen and Helle K. Iversen and Jens Erik Nielsen-Kudsk and Magnus Settergren and Christina Sj{\"o}strand and Risto Roine and David J R Hildick-Smith and J. David Spence and Lars H Thomassen},
  journal={The New England journal of medicine},
  volume={377 11},
BACKGROUND The efficacy of closure of a patent foramen ovale (PFO) in the prevention of recurrent stroke after cryptogenic stroke is uncertain. We investigated the effect of PFO closure combined with antiplatelet therapy versus antiplatelet therapy alone on the risks of recurrent stroke and new brain infarctions. METHODS In this multinational trial involving patients with a PFO who had had a cryptogenic stroke, we randomly assigned patients, in a 2:1 ratio, to undergo PFO closure plus… CONTINUE READING
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