Patchy interspecific sequence similarities efficiently identify positive cis-regulatory elements in the sea urchin.

@article{Yuh2002PatchyIS,
  title={Patchy interspecific sequence similarities efficiently identify positive cis-regulatory elements in the sea urchin.},
  author={C H Yuh and Clifford Brown and Carolina B Livi and Lee Rowen and Peter J. Clarke and Eric H. Davidson},
  journal={Developmental biology},
  year={2002},
  volume={246 1},
  pages={148-61}
}
We demonstrate that interspecific sequence conservation can provide a systematic guide to the identification of functional cis-regulatory elements within a large expanse of genomic DNA. The test was carried out on the otx gene of Strongylocentrotus purpuratus. This gene plays a major role in the gene regulatory network that underlies endomesoderm specification in the embryo. The cis-regulatory organization of the otx gene is expected to be complex, because the gene has three different start… CONTINUE READING

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