Patched2 modulates tumorigenesis in patched1 heterozygous mice.

  title={Patched2 modulates tumorigenesis in patched1 heterozygous mice.},
  author={Youngsoo Lee and Heather Lynnine Miller and Helen R C Russell and Kelli Boyd and Tom Curran and Peter J Mckinnon},
  journal={Cancer research},
  volume={66 14},
The sonic hedgehog (SHH) receptor Patched 1 (Ptch1) is critical for embryonic development, and its loss is linked to tumorigenesis. Germ line inactivation of one copy of Ptch1 predisposes to basal cell carcinoma and medulloblastoma in mouse and man. In many cases, medulloblastoma arising from perturbations of Ptch1 function leads to a concomitant up-regulation of a highly similar gene, Patched2 (Ptch2). As increased expression of Ptch2 is associated with medulloblastoma and other tumors, we… CONTINUE READING

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