Patched Knockout Mouse Models of Basal Cell Carcinoma

  title={Patched Knockout Mouse Models of Basal Cell Carcinoma},
  author={Frauke Nitzki and Marco Becker and Anke Frommhold and Walter J. Schulz-Schaeffer and Heidi Ann Hahn},
  booktitle={Journal of skin cancer},
Basal cell carcinoma (BCC) is the most common human tumor. Mutations in the hedgehog (HH) receptor Patched (PTCH) are the main cause of BCC. Due to their high and increasing incidence, BCC are becoming all the more important for the health care system. Adequate animal models are required for the improvement of current treatment strategies. A good model should reflect the situation in humans (i.e., BCC initiation due to Ptch mutations on an immunocompetent background) and should allow for (i… CONTINUE READING


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