Patch testing with the European baseline series fragrance markers: a 2016 update

  title={Patch testing with the European baseline series fragrance markers: a 2016 update},
  author={C Y Ung and J M White and Ian R. White and Piu Banerjee and J P McFadden},
  journal={British Journal of Dermatology},
Fragrance contact allergy is common and is currently screened for using the following European baseline series fragrance markers: fragrance mix (FM)I, FMII, Myroxylon pereirae and hydroxyisohexyl 3‐cyclohexene carboxaldehyde. 
Allergic contact dermatitis caused by hydroperoxides of limonene and dose‐response relationship—A repeated open application test (ROAT) study
Contact allergy to oxidized limonene, with hydroperoxides of limonene (Lim‐OOHs) as the main allergens, is common. However, high proportions of weak positive and doubtful patch test reactions haveExpand
Contact Allergy to Fragrance Mix II and Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde: A Retrospective Study by International Contact Dermatitis Research Group
The frequency of missed contact allergy to HICC when testing only with FM II was less than 0.5%, therefore questioning the need to test HicC separately in the ICDRG baseline series. Expand
How good is the Australian baseline series at detecting allergic contact dermatitis?
The aim of this study was to assess the efficacy of testing with the Australian Baseline Series in order to diagnose allergic contact dermatitis. Expand
An Update on Fragrance Contact Dermatitis
A more extensive group of fragrance markers should be included in the European Baseline Series, with at least limonene and linalool hydroperoxides and Evernia furfuracea. Expand
Contact Dermatitis: Emerging Trends.
The most noteworthy trends within the field of contact dermatitis are discussed, organized by allergen category, with particular attention to newer and/or controversial allergens. Expand
Extended patch‐test screening for fragrance contact allergy: findings and challenges
  • W. Uter
  • Medicine
  • The British journal of dermatology
  • 2018
The role of IL-36 in the pathogenesis of HS is still unknown, but according to a small randomized clinical trial, anakinra, an IL-1 receptor antagonist, has the potential to be an effective and safe treatment for severe HS. Expand
Myroxylon pereirae (balsam of Peru): Still worth testing?
Because Myroxylon pereirae (MP), or balsam of Peru, is nowadays almost not used “as such,” and fragrance mix 1 (FM1) apparently is more sensitive in detecting fragrance allergy, the usefulness ofExpand
Contact allergy to citral and its constituents geranial and neral, coupled with reactions to the prehapten and prohapten geraniol
Citral is commonly used as a fragrance and flavor material and consists of the aldehydes geranial and neral. Citral is included in fragrance mix (FM) II. Geranial and neral have also been identifiedExpand
Myroxylon pereirae resin (balsam of Peru) – A critical review of the literature and assessment of the significance of positive patch test reactions and the usefulness of restrictive diets
In this article, contact allergy to Myroxylon pereirae resin (MP) (balsam of Peru) is reviewed and suggestions are given for further research to address questions thus far unanswered and to improve patient care. Expand
Exposure source for skin sensitizing hydroperoxides of limonene and linalool remains elusive: An analytical market surveillance.
  • A. Natsch, Marco Nägelin, +4 authors Cecile González
  • Medicine, Chemistry
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2019
It is indicated that concentrations of HP in consumer products and patient products are orders of magnitude below sensitizing doses in animal tests. Expand


Baseline series fragrance markers fail to predict contact allergy
Negative patch test results with fragrance allergy markers in the European baseline series do not always predict a negative reaction to individual fragrance substances.
Contact sensitization to fragrances in the general population: a Koch’s approach may reveal the burden of disease
Background  Contact sensitization to fragrance mix (FM) I and Myroxylon pereirae (MP) is common among European patients with dermatitis. Recently, FM II was included in the European baseline seriesExpand
Design and Feasibility of an International Study Assessing the Prevalence of Contact Allergy to Fragrances in the General Population: The European Dermato-Epidemiology Network Fragrance Study
The methodology and the reliability of instruments adopted and the feasibility based on a pilot phase are reported and the EDEN Fragrance Study is feasible and able to provide useful data on fragrance allergy. Expand
European Society of Contact Dermatitis guideline for diagnostic patch testing – recommendations on best practice
The present guideline summarizes all aspects of patch testing for the diagnosis of contact allergy in patients suspected of suffering, or having been suffering, from allergic contact dermatitis orExpand
Commission Regulation (EU) 2017/1410 of 2 August 2017 amending Annexes II and III to Regulation (EC) No 1223/2009 of the European Parliament and of the Council on cosmetic products
  • Official J European Union
  • 2017