Patch-clamping of the inner mitochondrial membrane reveals a voltage-dependent ion channel

@article{Sorgato1987PatchclampingOT,
  title={Patch-clamping of the inner mitochondrial membrane reveals a voltage-dependent ion channel},
  author={Maria Catia Sorgato and Bernhard U. Keller and Walter Stuehmer},
  journal={Nature},
  year={1987},
  volume={330},
  pages={498-500}
}
The prime function of mitochondria is to provide the cell with adenosine triphosphate (ATP). ATP synthesis is driven by the protonmotive force (δp), which is generated and maintained across the inner mitochondrial membrane (IMM) by the activity of the respiratory chain1. It is widely believed that the IMM is unlikely to contain ion channels like those present in the plasma membrane, because the high rates of ion transport characteristic of open channels would be expected to dissipate the δp… CONTINUE READING