Patch-clamp characterisation of somatostatin-secreting -cells in intact mouse pancreatic islets.

@article{Gpel2000PatchclampCO,
  title={Patch-clamp characterisation of somatostatin-secreting -cells in intact mouse pancreatic islets.},
  author={Sven O. G{\"o}pel and Takahiro Kanno and Sebastian Barg and Patrik Rorsman},
  journal={The Journal of physiology},
  year={2000},
  volume={528 Pt 3},
  pages={497-507}
}
The perforated patch whole-cell configuration of the patch-clamp technique was applied to superficial cells in intact mouse pancreatic islets. Three types of electrical activity were observed corresponding to alpha-, beta- and delta-cells. The delta-cells were electrically active in the presence of glucose but lacked the oscillatory pattern seen in the beta-cells. By contrast, the alpha-cells were electrically silent at high glucose concentrations but action potentials could be elicited by… CONTINUE READING
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