Patch-clamp analysis of synaptic transmission to cerebellar purkinje cells of prion protein knockout mice.

@article{Herms1995PatchclampAO,
  title={Patch-clamp analysis of synaptic transmission to cerebellar purkinje cells of prion protein knockout mice.},
  author={Jochen Herms and H A Kretzchmar and Stefan Titz and Bernhard U. Keller},
  journal={The European journal of neuroscience},
  year={1995},
  volume={7 12},
  pages={2508-12}
}
The prion protein (PrP) plays a pivotal role in transmissible spongiform encephalopathies such as Creutzfeldt-Jakob disease in humans and scrapie and bovine spongiform encephalopathy in animals. Previous experiments have suggested that the normal cellular prion protein (PrPc) is involved in synaptic function in the hippocampus. Here, we utilized the controlled recording conditions of the patch-clamp technique to investigate the synaptic function of prion protein in cerebellar Purkinje cells. By… CONTINUE READING

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