Patch Clamp on the Luminal Membrane of Exocrine Gland Acini from Frog Skin (Rana esculenta) Reveals the Presence of Cystic Fibrosis Transmembrane Conductance Regulator–like Cl− Channels Activated by Cyclic AMP

@article{Srensen1998PatchCO,
  title={Patch Clamp on the Luminal Membrane of Exocrine Gland Acini from  Frog Skin (Rana esculenta) Reveals the Presence of Cystic Fibrosis  Transmembrane Conductance Regulator–like Cl− Channels Activated by  Cyclic AMP },
  author={Jakob Balslev S\orensen and Erik Hviid Larsen},
  journal={The Journal of General Physiology},
  year={1998},
  volume={112},
  pages={19 - 31}
}
Chloride channels in the luminal membrane of exocrine gland acini from frog skin (Rana esculenta) constituted a single homogeneous population. In cell-attached patches, channels activated upon exposure to isoproterenol, forskolin, or dibutyryl-cAMP and isobutyl-1-methyl-xanthine rectified in the outward direction with a conductance of 10.0 +/- 0.4 pS for outgoing currents. Channels in stimulated cells reversed at 0 mV applied potential, whereas channels in unstimulated cells reversed at… CONTINUE READING

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