Pat1 contains distinct functional domains that promote P-body assembly and activation of decapping.

@article{Pilkington2008Pat1CD,
  title={Pat1 contains distinct functional domains that promote P-body assembly and activation of decapping.},
  author={Guy R. Pilkington and R. O. Parker},
  journal={Molecular and cellular biology},
  year={2008},
  volume={28 4},
  pages={
          1298-312
        }
}
  • Guy R. Pilkington, R. O. Parker
  • Published in
    Molecular and cellular…
    2008
  • Biology, Medicine
  • The control of mRNA degradation and translation are important aspects of gene regulation. Recent results suggest that translation repression and mRNA decapping can be intertwined and involve the formation of a quiescent mRNP, which can accumulate in cytoplasmic foci referred to as P bodies. The Pat1 protein is a key component of this complex and an important activator of decapping, yet little is known about its function. In this work, we analyze Pat1 in Saccharomyces cerevisiae function by… CONTINUE READING

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