Past matrix stiffness primes epithelial cells and regulates their future collective migration through a mechanical memory.

Abstract

During morphogenesis and cancer metastasis, grouped cells migrate through tissues of dissimilar stiffness. Although the influence of matrix stiffness on cellular mechanosensitivity and motility are well-recognized, it remains unknown whether these matrix-dependent cellular features persist after cells move to a new microenvironment. Here, we interrogate… (More)
DOI: 10.1016/j.biomaterials.2017.09.012

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