Past adult lead exposure is linked to neurodegeneration measured by brain MRI

@article{Stewart2006PastAL,
  title={Past adult lead exposure is linked to neurodegeneration measured by brain MRI},
  author={Walter F. Stewart and Brian S. Schwartz and Christos Davatzikos and D Shen and D Liu and X. Wu and Andrew C Todd and W. Shi and Simon Bassett and D Youssem},
  journal={Neurology},
  year={2006},
  volume={66},
  pages={1476 - 1484}
}
Objective: To determine whether cumulative lead dose in former organolead workers was associated with MRI measures of white matter lesions (WML) and global and structure-specific brain volumes. Methods: MRIs, tibia lead, and other measures were obtained from 532 former organolead workers with a mean age of 56 years and a mean of 18 years since last occupational exposure to lead. Cumulative lead dose was measured by tibia lead, obtained by X-ray fluorescence, and expressed as μg lead per gram of… Expand
Evaluation of cumulative lead dose and longitudinal changes in structural MRI in former organolead workers
Objective—We evaluated whether tibia lead was associated with longitudinal change in brain volumes and white matter lesions in male former lead workers and population-based controls in whom we haveExpand
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TLDR
C cumulative lead dose was associated with earlier persistent effects on brain structure but not with additional worsening during 5 years, and Tibia lead was not associated with change in brain volumes or white matter lesion scores. Expand
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Longitudinal analysis of the Korean and organolead cohort indicate that the effect of lead is persistent, and a significant proportion of what is considered to be "normal" age-related cognitive decline may be due to past exposure to neurotoxicants such as lead. Expand
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TLDR
There was no association with bone lead level and recency of exposure, suggesting that cumulative body burden is most likely responsible for the progressive cognitive decrement evidenced with vulnerability because of aging. Expand
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TLDR
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Lead and cognitive function in adults: A questions and answers approach to a review of the evidence for cause, treatment, and prevention
TLDR
The results of these studies support the inference that a proportion of what has been termed ‘normal’ age-related cognitive decline may, in fact, be due to exposure to neurotoxicants such as lead. Expand
Environmental lead exposure and cognitive function in community-dwelling older adults
TLDR
A portion of age-related decrements in cognitive function in this population may be associated with earlier lead exposure, which may have persistent effects on cognitive function. Expand
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TLDR
These data suggest that low-level, gestational lead exposure in a mouse model produces minimal changes observed by MRI, and mean diffusivity in the hippocampus showed significant effects of lead exposure and gender. Expand
The influence of age of lead exposure on adult gray matter volume.
TLDR
It is demonstrated that maximum blood lead levels do not fully account for gray matter changes associated with childhood lead exposure, particularly in the frontal lobes of young men. Expand
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