Past, present, and future perspectives of heparins in clinical settings and the role of impaired renal function.

  • Job Harenberg
  • Published 2016 in International journal of cardiology


Heparin, whose discovery goes back one hundred years, was first detected as a thromboplastin from liver tissue, and its anticoagulant action was only identified later. The procoagulant action of heparin, which was later characterized as an immunologic reaction by binding to platelet-factor IV, presenting as heparin-induced thrombocytopenia, remains as a… (More)
DOI: 10.1016/S0167-5273(16)12003-0


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