Passively transferred human NMO-IgG exacerbates demyelination in mouse experimental autoimmune encephalomyelitis


BACKGROUND Neuromyelitis optica (NMO) is a devastating inflammatory disorder of the optic nerves and spinal cord characterized by frequently recurring exacerbations of humoral inflammation. NMO is associated with the highly specific NMO-IgG biomarker, an antibody that binds the aquaporin-4 water channel. Aquaporin-4 is present on glial endfeet in the… (More)
DOI: 10.1186/1471-2377-13-104


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