Passively acquired autoimmunity and the maternal fetal dyad in systemic lupus erythematosus

@article{Buyon1986PassivelyAA,
  title={Passively acquired autoimmunity and the maternal fetal dyad in systemic lupus erythematosus},
  author={Jill P Buyon and Ilona S. Szer},
  journal={Springer Seminars in Immunopathology},
  year={1986},
  volume={9},
  pages={283-304}
}
Neonatal lupus syndromes consist of transient cutaneous and hematologic abnormalities and permanent cardiac disorders all of which result from a common pathogenetic mechanism, the passive transfer of maternal autoantibodies. Detrimental antibodies such as SSA/Ro and SSB/La gain access to the fetal circulation via the normal active transport system of the trophoblast tissue which is operative after 20 weeks gestation. Despite functional maturation of the cardiac conduction system by 16 weeks… CONTINUE READING
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