Passive transfer of arthritis to mice by injection of human anti-type II collagen antibody.

@article{Wooley1984PassiveTO,
  title={Passive transfer of arthritis to mice by injection of human anti-type II collagen antibody.},
  author={Paul H. Wooley and Harvinder S. Luthra and Satwinder K. Singh and A R Huse and John M. Stuart and Chella S. David},
  journal={Mayo Clinic proceedings},
  year={1984},
  volume={59 11},
  pages={737-43}
}
The serum IgG fraction from a patient with seronegative rheumatoid-like arthritis which contained a high anti-type II collagen antibody titer was injected intravenously into mice susceptible to type II collagen-induced arthritis. A mild, transient, inflammatory arthritis was observed in 20 to 25% of the animals, whereas histologic signs of disease were evident in most of the injected mice. Purified human anti-type II collagen immunoglobulin injected into the knee joints of mice was also shown… CONTINUE READING