Passive stiffness changes in soleus muscles from desmin knockout mice are not due to titin modifications

@article{Anderson2002PassiveSC,
  title={Passive stiffness changes in soleus muscles from desmin knockout mice are not due to titin modifications},
  author={J. Anderson and Venus Joumaa and Laurence Stevens and Ciprian Neagoe and Zhizhong Li and Yvonne Mounier and W. Linke and Francis Goubel},
  journal={Pfl{\"u}gers Archiv},
  year={2002},
  volume={444},
  pages={771-776}
}
Passive stiffness was found to be increased in mouse soleus muscles lacking desmin. Because titin is considered to be the major source of muscle elasticity, the stiffening might be explainable by titin adaptation. To test this, passive mechanical properties of single skinned fibres of soleus muscles from desmin knockout and control mice were analysed by using various extension tests. Titin expression was studied by SDS-gel electrophoresis. Absence of desmin did not modify either electrophoretic… CONTINUE READING