Passive serum therapy with polyclonal antibodies against Mycobacterium tuberculosis protects against post-chemotherapy relapse of tuberculosis infection in SCID mice☆

@article{Guirado2006PassiveST,
  title={Passive serum therapy with polyclonal antibodies against Mycobacterium tuberculosis protects against post-chemotherapy relapse of tuberculosis infection in SCID mice☆},
  author={Evelyn Guirado and Isabel Amat and Olga L Gil and Jorge J. Riera Diaz and Virginia Arcos and Neus C{\'a}ceres and Vicenç Ausina and P E Cardona},
  journal={Microbes and infection},
  year={2006},
  volume={8 5},
  pages={
          1252-9
        }
}
We investigated the protective role of immune-sera against reactivation of Mycobacterium tuberculosis infection in SCID mice and found that passive immunization with sera obtained from mice treated with detoxified M. tuberculosis extracts (delivered in liposomes in a composition known as RUTI) exerted significant protection. Our SCID mouse model consisted of aerosol infection by M. tuberculosis, followed by 3 to 8weeks of chemotherapy with isoniazid+rifampicin (INH+RIF) (25 and 10mg/kg… CONTINUE READING
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