Passive or active immunization with myelin basic protein promotes recovery from spinal cord contusion.

@article{Hauben2000PassiveOA,
  title={Passive or active immunization with myelin basic protein promotes recovery from spinal cord contusion.},
  author={Ehud Hauben and Oleg Butovsky and Uri Nevo and Eti Yoles and Gila Moalem and Evgenia Agranov and Felix Mor and Raya Leibowitz-Amit and E Pevsner and Solange Akselrod and Michal Neeman and Irun R. Cohen and Michal Schwartz},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2000},
  volume={20 17},
  pages={6421-30}
}
Partial injury to the spinal cord can propagate itself, sometimes leading to paralysis attributable to degeneration of initially undamaged neurons. We demonstrated recently that autoimmune T cells directed against the CNS antigen myelin basic protein (MBP) reduce degeneration after optic nerve crush injury in rats. Here we show that not only transfer of T cells but also active immunization with MBP promotes recovery from spinal cord injury. Anesthetized adult Lewis rats subjected to spinal cord… CONTINUE READING
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