Passive load and angiotensin II evoke differential responses of gene expression and protein synthesis in cardiac myocytes.

Abstract

This study introduced an improved model of loaded adult cardiocytes to address a proposed requirement for angiotensin II (Ang II) in the transduction pathway between load on the cardiac myocyte and its early anabolic responses of gene expression and acceleration of protein synthesis. The isolated cardiocytes were subjected to passive load by step increments… (More)

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