Passive immunization of rhesus macaques against SIV infection and disease.

  title={Passive immunization of rhesus macaques against SIV infection and disease.},
  author={Murray B. Gardner and Andr{\'e} Rosenthal and Merilyn Jennings and John A. Yee and L Antipa and Elsa Robinson},
  journal={AIDS research and human retroviruses},
  volume={11 7},
To evaluate the role of humoral immunity against simian immunodeficiency virus (SIV), we tested whether passive immunization with plasma from SIVmac251 vaccine-protected or healthy infected animals would protect rhesus monkeys against intravenous infection with ten 50% animal infectious doses of the cell-free homologous virus. The challenge dose of this SIVmac251 virus stock had previously caused persistent infection in all (21 of 21) nonimmunized controls. A plasma pool was obtained from a… CONTINUE READING
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