Passive immunization of pigs with bispecific llama single-domain antibody fragments against foot-and-mouth disease and porcine immunoglobulin.

@article{Harmsen2008PassiveIO,
  title={Passive immunization of pigs with bispecific llama single-domain antibody fragments against foot-and-mouth disease and porcine immunoglobulin.},
  author={Michiel M. Harmsen and Helmi P D Fijten and Aldo Dekker and Phaedra L. Ebl{\'e}},
  journal={Veterinary microbiology},
  year={2008},
  volume={132 1-2},
  pages={56-64}
}
Foot-and-mouth disease (FMD) is a contagious viral disease of cloven-hoofed animals that occasionally causes outbreaks in Europe. We aim to develop an immunotherapy that confers rapid protection against FMD in outbreak situations. For this purpose, we previously isolated llama single-domain antibody fragments (VHHs) binding to FMDV or porcine immunoglobulin (pIg). The pIg binding VHHs can be genetically fused to other VHHs, resulting in so-called VHH2s. As compared to non-pIg binding VHHs such… CONTINUE READING

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