Passive hemolysis by serum and cobra venom factor: a new mechanism inducing membrane damage by complement.

@article{Pickering1969PassiveHB,
  title={Passive hemolysis by serum and cobra venom factor: a new mechanism inducing membrane damage by complement.},
  author={Richard J. Pickering and Marla R. Wolfson and RobertA. Good and Henry Gewurz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1969},
  volume={62 2},
  pages={
          521-7
        }
}
The studies presented here indicate that activation of the complement (C') system by a foreign protein will cause membrane injury and passive lysis of unsensitized erythrocytes present at the time of the reaction. These observations suggest that in addition to the classical antibody-C'-induced cytolysis, there are alternative pathways or mechanisms for activation and participation of the terminal C' components in the production of cell membrane injury. We have shown that a substance derived… CONTINUE READING
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