Passive exposure to a contextual discriminative stimulus reinstates cocaine-seeking behavior in rats.

@article{Alleweireldt2001PassiveET,
  title={Passive exposure to a contextual discriminative stimulus reinstates cocaine-seeking behavior in rats.},
  author={Andrea T. Alleweireldt and Suzanne M. Weber and Janet L. Neisewander},
  journal={Pharmacology, biochemistry, and behavior},
  year={2001},
  volume={69 3-4},
  pages={555-60}
}
A significant problem in treating cocaine dependence is craving-induced relapse elicited by inadvertent (i.e., passive) exposure to cocaine-paired stimuli. Extinction/reinstatement of cocaine-seeking behavior in animals has been used to investigate this phenomenon. Most studies using this model have examined reinstatement by response-contingent exposure to discrete cocaine-paired stimuli. The present study expanded this research by examining passive (i.e., not contingent upon an operant… CONTINUE READING

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