Passive diffusion of weak organic electrolytes across Caco-2 cell monolayers: uncoupling the contributions of hydrodynamic, transcellular, and paracellular barriers.

Abstract

A systematic approach was used to demonstrate the quantitative interplay of pH, pKa, lipophilicity, charged and uncharged molecular species, molecular size, aqueous diffusivity, and stirring in passive transport across the aqueous boundary layer, microporous filter support, and transcellular and paracellular barriers in Caco-2 cell monolayers. The… (More)

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@article{Adson1995PassiveDO, title={Passive diffusion of weak organic electrolytes across Caco-2 cell monolayers: uncoupling the contributions of hydrodynamic, transcellular, and paracellular barriers.}, author={Anthony Adson and Philip S. Burton and Thomas J. Raub and Craig L. Barsuhn and Kenneth L. Audus and Norman F. H. Ho}, journal={Journal of pharmaceutical sciences}, year={1995}, volume={84 10}, pages={1197-204} }