Passive control of cell locomotion using micropatterns: the effect of micropattern geometry on the migratory behavior of adherent cells.

@article{Yoon2012PassiveCO,
  title={Passive control of cell locomotion using micropatterns: the effect of micropattern geometry on the migratory behavior of adherent cells.},
  author={Sang-Hee Yoon and Young Kyun Kim and Eui Don Han and Young Ho Seo and Byeong Hee Kim and Mohammad R. Kaazempur Mofrad},
  journal={Lab on a chip},
  year={2012},
  volume={12 13},
  pages={
          2391-402
        }
}
Directed cell migration is critical to a variety of biological and physiological processes. Although simple topographical patterns such as parallel grooves and three-dimensional post arrays have been studied to guide cell migration, the effect of the dimensions and shape of micropatterns, which respectively represent the amount and gradient of physical spatial cues, on cell migration has not yet been fully explored. This motivates a quantitative characterization of cell migration in response to… 
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biomechanics.berkeley.edu
35 Citations
Background Citations
8
Methods Citations
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35 Citations

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Citation Type

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TLDR
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TLDR
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TLDR
A device that is able to apply surface acoustic waves to a cell culture substrate is developed and the effect of propagating acoustic waves on collective cell migration is investigated and it is revealed that unidirectional cell migration was enhanced at a critical wave intensity and that it was suppressed as the intensity was further increased.
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TLDR
Seed control or tEMT NMuMG cells on the 2D patterns consisted of 1 μm or 5 μm line-widths and groove or cone patterns on either 2 MPa or 4 MPa polydimethylsiloxane (PDMS) substrates to study the effects of substrate stiffness and topography on the migration of cells before or after transforming growth factor-β1 (TGF- β1)-induced EMT (tEMT).
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