Passive avoidance training results in increased responsiveness of voltage- and ligand-gated calcium channels in chick brain synaptoneurosomes

  title={Passive avoidance training results in increased responsiveness of voltage- and ligand-gated calcium channels in chick brain synaptoneurosomes},
  author={Elżbieta Salińska and Dipesh Chaudhury and Rachel C. Bourne and Steven Peter Russell Rose},
Long-Term Memory Formation in the Chick Requires Mobilization of Ryanodine-Sensitive Intracellular Calcium Stores
Calcium release from ryanodine-sensitive intracellular stores may be a necessary stage in the early phase of the molecular cascade leading to the synaptic modulation required for long-term memory storage.
God's organism? The chick as a model system for memory studies.
  • S. Rose
  • Biology
    Learning & memory
  • 2000
The young chick is a powerful model system in which to study the biochemical and morphological processes underlying memory formation and the spatio-temporal distribution of the putative memory trace.
Molecular changes in the intermediate medial mesopallium after a one trial avoidance learning in immature and mature chickens
The results imply that the molecular changes induced by learning a behavioral task are faster in mature than immature brain and may involve a different balance of intracellular signaling pathways.
Neural and synaptic plasticity in the chick brain after passive avoidance learning
Radioimmunoassay measurements of cortisol in chick forebrain tissue demonstrated longer term increase in levels of steroid in the chick Hp compared to arcopallium and striatum mediale 20 minutes after training, indicating that PAL is a stressful experience which may explain synaptic density and cell proliferation reduction observed after PAL.


Inhibitory Avoidance Training Induces Rapid and Selective Changes in3[H]AMPA Receptor Binding in the Rat Hippocampal Formation
Rats submitted to a one-trial inhibitory avoidance training showed a rapid, selective, and specific increase in 3[H]AMPA binding in the hippocampal formation, supporting the hypothesis that hippocampal AMPA receptors are involved in the neural mechanisms underlying certain forms of learning and memory.
Passive Avoidance Training and Recall are Associated With Increased Glutamate Levels in the Intermediate Medial Hyperstriatum Ventrale of the Day-Old Chick
The results suggest that changes in extra-cellular glutamate levels in the intermediate medial hyperstriatum ventrale accompany pecking at either the water- or the methylanthranylate-bead, and the taste of the aversant may be responsible for the greater increases found in methylannorthern-trained birds.
Postsynaptic factors in the expression of long-term potentiation (LTP): increased glutamate receptor binding following LTP induction in vivo.
Qualitative autoradiography results suggest that a modification in postsynaptic AMPA receptors plays a role in the expression of synaptic enhancement following LTP induction in the hippocampus.
The Involvement of Ca2+/Calmodulin-Dependent Protein Kinase in Memory Formation in Day-Old Chicks
Day-old chicks trained on a single trial passive avoidance learning task showed a significant increase, relative to untrained controls, in activity of the Ca2+/calmodulin-dependent protein kinase
Antagonism of NMDA receptors impairs acquisition but not retention of olfactory memory.
Examination of the effect of chronic intraventricular administration of D-amino-phosphono-valeric acid (AP5), a competitive NMDA receptor antagonist, on olfactory discrimination and avoidance learning found that one-way active avoidance learning was not affected by chronic infusion of AP5.
The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro
It is established that D-AP5 impairs spatial learning in a linear dose-dependent manner, highly correlated with its corresponding impairment of hippocampal LTP in vivo, and support is offered for the hypothesis that activation of NMDA receptors is necessary for certain kinds of learning.
Presynaptic Changes in Long‐Term Potentiation: Elevated Synaptosomal Calcium Concentration and Basal Phosphoinositide Turnover in Dentate Gyrus
Findings are consistent with the hypothesis that the increase in glutamate release associated with long‐term potentiation may be stimulated by arachidonic acid, as a result of an increase in intrasynaptosomal calcium concentration, perhaps occurring as a consequence of arachidonate‐stimulated phosphoinositide metabolism.