Passive avoidance behaviour deficit in the mdx mouse.

  title={Passive avoidance behaviour deficit in the mdx mouse.},
  author={Francesco Muntoni and Anna Mateddu and Giovanni Serra},
  journal={Neuromuscular disorders : NMD},
  volume={1 2},
Thirty per cent of boys with Duchenne muscular dystrophy (DMD) suffer from various degrees of mental retardation. Since dystrophin, the protein absent in muscles of boys with DMD, is produced also in the brain, it was postulated that the deficiency of brain dystrophin might account for the mental retardation found in DMD boys. The mdx mouse, a mouse model of DMD, fails to produce dystrophin in muscle and brain. This prompted us to study the cognitive function of these animals. Learning and… CONTINUE READING