Passive and active mechanisms trap activated CD8+ T cells in the liver.

@article{John2004PassiveAA,
  title={Passive and active mechanisms trap activated CD8+ T cells in the liver.},
  author={Beena John and Ian Nicholas Crispe},
  journal={Journal of immunology},
  year={2004},
  volume={172 9},
  pages={5222-9}
}
The liver is a site where activated CD8(+) T cells are trapped and destroyed at the end of an immune response. The intrahepatic accumulation of activated murine TCR transgenic CD8(+) T cells was significantly reduced when either ICAM-1 or VCAM-1 was blocked by specific Ab. These two adhesion mechanisms account for essentially all the trapping of activated CD8(+) T cells in the mouse liver. Although the ICAM-1-mediated trapping depends on the capacity of the vasculature and/or the parenchymal… CONTINUE READING

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