Passive anaphylaxis in human lung fragments as a model for testing anti-allergic drugs: its variability and constraints.

@article{Young1983PassiveAI,
  title={Passive anaphylaxis in human lung fragments as a model for testing anti-allergic drugs: its variability and constraints.},
  author={K. D. Young and M. Church},
  journal={International archives of allergy and applied immunology},
  year={1983},
  volume={70 2},
  pages={
          138-42
        }
}
  • K. D. Young, M. Church
  • Published 1983
  • Medicine
  • International archives of allergy and applied immunology
Histamine release from human lung fragments, passively sensitized and challenged with antigen under standardized experimental conditions, varied between 0 and 41.2% (mean +/- SD 15.6 +/- 10.0%) in 89 experiments. Over 41 lungs, the mean coefficient of variation for release from 10 to 28 tissue replicates was 21.4% (range 7-44%). Sodium cromoglycate and chlorpromazine were both partial antagonists of histamine release producing, at best, 30-40% inhibition. The cromoglycate analogue, bufrolin… Expand
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